Complete Information on Blood coagulation disorders
Coagulation is initiated almost instantly after an injury to the blood vessel damages the endothelium.
Blood coagulation is part of an important host defense mechanism termed hemostasis. Upon vessel injury, platelets adhere to macromolecules in the subendothelial tissues and then aggregate to form the primary hemostatic plug. Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The platelets stimulate local activation of plasma coagulation factors, leading to generation of a fibrin clot that reinforces the platelet aggregate.
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